Vernole P, Tedeschi B, Melino G, Pianca C, Nicoletti B
Department of Public Health and Cell Biology, 2nd University of Rome, Italy.
Anticancer Res. 1992 Sep-Oct;12(5):1419-21.
In a previous study we demonstrated spontaneous fragility and hypersensitivity to fragile site induction by aphidicolin in lymphocytes from some neuroblastoma patients and their parents. Here we report data based on a total of 40 patients and 37 families. Possible correlations between higher sensitivity to aphidicolin and a variety of personal and clinical characteristics were verified. Patients with a poor prognosis generally proved to be more susceptible to fragile site induction.
在之前的一项研究中，我们证明了某些神经母细胞瘤患者及其父母的淋巴细胞中存在自发脆性以及对阿非科林诱导脆性位点的超敏反应。在此，我们报告基于总共40名患者和37个家庭的数据。验证了对阿非科林较高敏感性与各种个人和临床特征之间可能存在的相关性。预后较差的患者通常被证明更容易诱导出脆性位点。
