Mikhaĭlovskaia O V, Viktorova N A, Krasnova O R, Titova A A, Koliubaeva S N
Tsitologiia. 2005;47(1):83-8.
Patients with lymphomas were shown to have authentically a higher frequency of fragile sites, both spontaneous and induced by aphidikoline expression, in comparison with the control group. Differential sensitivity of chromosomes caused by the action of aphidikolin was revealed. The fragility of chromosomes 9 and 11 in patients with lymphomas on sites 9q31-32 and 11p13-14 was authentically higher (alpha = 0.05) than that in healthy individuals. Site 9q31-32 appeared to be strictly specific for lymphoma disease.
与对照组相比，淋巴瘤患者体内无论是自发的还是由阿非迪科林表达诱导产生的脆性位点频率确实更高。研究揭示了阿非迪科林作用导致的染色体敏感性差异。淋巴瘤患者9号和11号染色体在9q31 - 32和11p13 - 14位点的脆性确实高于健康个体（α = 0.05）。9q31 - 32位点似乎是淋巴瘤疾病所特有的。
