Sweet M B, Thonar E J, Immelman A R, Solomon L
Ann Rheum Dis. 1977 Oct;36(5):387-98. doi: 10.1136/ard.36.5.387.
Quantitative and qualitative variations in glycosaminoglycan content were studied in fibrillated, intact, and osteophytic cartilage of the human femoral head in osteoarthrosis. Total glycosaminoglycan content was reduced in fibrillated, unchanged in intact, and raised in osteophytic cartilage. In fibrillated and osteophytic cartilage the ratio of chondroitin sulphate to keratan sulphate was high and therefore resembled immature cartilage. Hyaluronic acid was present in reduced amount in all osteoarthrotic material. Proportionally more proteoglycans were extractable by 0-15 M NaCl and 4 M guanidinium chloride from the diseased cartilage than from normal cartilage, and all proteoglycans irrespective of buoyant density were carbohydrate deficient. It is postulated that the changes described are compatible with collagen and matrix disruption due to focal overloading and the general attempt at repair.
对骨关节炎患者股骨头的纤维化、完整及骨赘性软骨中的糖胺聚糖含量进行了定量和定性研究。纤维化软骨中的总糖胺聚糖含量降低，完整软骨中的含量无变化，而骨赘性软骨中的含量升高。在纤维化和骨赘性软骨中，硫酸软骨素与硫酸角质素的比例较高，因此类似于未成熟软骨。所有骨关节炎材料中的透明质酸含量均减少。与正常软骨相比，从患病软骨中可被0 - 15M氯化钠和4M氯化胍提取的蛋白聚糖比例更高，且所有蛋白聚糖无论其浮力密度如何均缺乏碳水化合物。据推测，所描述的这些变化与因局部过载及整体修复尝试导致的胶原蛋白和基质破坏是相符的。
