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[肺鳞状细胞癌的超微结构作为手术治疗的预后因素]

[Ultrastructure of pulmonary squamous cell carcinoma as a prognostic factor in surgical treatment].

作者信息

Raĭkhlin N T, Smirnova E A, Davydov M I, Polotskiĭ B E, Malaev S G

出版信息

Arkh Patol. 1992;54(4):15-20.

PMID:1444849
Abstract

163 operated on patients were divided into 2 groups: the 1st group--those surviving 5 years without recurrence (44.2%) and the 2nd group--those dying earlier from the tumour progression (55.8%). Central carcinoma was in 104, peripheral one in 59 cases. The number of dark cells (DC) and the degree of desmosome development revealed ultrastructurally have the greatest practical importance as the favourable course in the 1st group was associated with the absence or low number of DC (7%) and the high number of desmosomes (89%). These indices were found in the 2nd group in 86 and 41%, respectively. Both indices are of independent importance and are not associated with the spread of the carcinoma. The level of DC is of greater importance. Prognosis of the squamous cell carcinoma is the worse the higher is DC number in the tumour and the lower the desmosome number.

摘要

163例接受手术的患者被分为两组:第一组为存活5年且无复发的患者(44.2%),第二组为因肿瘤进展而较早死亡的患者(55.8%)。中央型癌104例,周围型癌59例。超微结构显示的暗细胞(DC)数量和桥粒发育程度具有最大的实际意义,因为第一组良好的病程与DC数量缺失或较少(7%)以及桥粒数量较多(89%)有关。在第二组中,这些指标分别为86%和41%。这两个指标都具有独立的重要性,且与癌的扩散无关。DC水平更为重要。肿瘤中DC数量越高且桥粒数量越低,鳞状细胞癌的预后就越差。

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