幼兔体内同源和异源血清蛋白的代谢
The metabolism of homologous and heterologous serum proteins in baby rabbits.
作者信息
HUMPHREY J H
出版信息
Immunology. 1961 Oct;4(4):380-7.
The catabolism of I-labelled rabbit and human albumin and γ globulin has been studied in baby rabbits from the 1st to the 6th week after birth. The half-lives, based in plasma concentrations corrected for growth, were approximately constant throughout this period, and were as follows: rabbit albumin and human albumin, about 6 days; rabbit γ globulin and human γ globulin, 12–14 days. Until the age of about 3 weeks, renal excretion of iodide was very inefficient. Consequently free I accumulated in the stomachs, and the whole body radio-activity greatly exceeded that due to retained labelled protein.
对出生后第1至6周的幼兔体内I标记的兔和人白蛋白及γ球蛋白的分解代谢进行了研究。根据经生长校正后的血浆浓度计算，半衰期在整个这一时期大致恒定，具体如下：兔白蛋白和人白蛋白约为6天；兔γ球蛋白和人γ球蛋白为12 - 14天。在大约3周龄之前，碘化物的肾排泄效率很低。因此，游离碘在胃中蓄积，全身放射性大大超过因保留的标记蛋白所致的放射性。
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