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Effect of mercuric chloride on serum protein catabolism and protein content of rabbit kidney.
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Induction of tolerance to heterologous proteins and their catabolism in C57BL/6 mice.C57BL/6小鼠对异源蛋白的耐受性诱导及其分解代谢
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本文引用的文献

1
The metabolism of serum proteins in neonatal rabbits.新生兔血清蛋白的代谢
J Gen Physiol. 1960 Jul;43(6):1047-59. doi: 10.1085/jgp.43.6.1047.
2
Efficient trace-labelling of proteins with iodine.用碘对蛋白质进行高效的示踪标记。
Nature. 1958 Jul 5;182(4627):53. doi: 10.1038/182053a0.
3
Immunological unresponsiveness in rabbits produced by neonatal injection of defined antigens.新生兔注射特定抗原后产生的免疫无反应性。
J Exp Med. 1958 Aug 1;108(2):227-50. doi: 10.1084/jem.108.2.227.
4
The behavior of I 131-labeled plasma proteins in vivo.I 131标记的血浆蛋白在体内的行为。
Ann N Y Acad Sci. 1957 Aug 30;70(1):19-25. doi: 10.1111/j.1749-6632.1957.tb35374.x.
5
Studies of zone electrophoresis in vertical columns. II. Zone electrophoresis of serum proteins.垂直柱区带电泳的研究。II. 血清蛋白的区带电泳
Biochim Biophys Acta. 1957 Oct;26(1):159-69. doi: 10.1016/0006-3002(57)90067-7.
6
The survival of globulins absorbed from the gut in suckling rats.乳鼠肠道吸收的球蛋白的存活情况。
Biochem J. 1957 Aug;66(4):584-7. doi: 10.1042/bj0660584.
7
Studies on gamma globulin. I. Distribution and metabolism of antibodies and gamma globulin in hypogammaglobulinemic patients.γ球蛋白研究。I. 低γ球蛋白血症患者体内抗体及γ球蛋白的分布与代谢
J Lab Clin Med. 1957 Apr;49(4):607-16.

幼兔体内同源和异源血清蛋白的代谢

The metabolism of homologous and heterologous serum proteins in baby rabbits.

作者信息

HUMPHREY J H

出版信息

Immunology. 1961 Oct;4(4):380-7.

PMID:14449976
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1424114/
Abstract

The catabolism of I-labelled rabbit and human albumin and γ globulin has been studied in baby rabbits from the 1st to the 6th week after birth. The half-lives, based in plasma concentrations corrected for growth, were approximately constant throughout this period, and were as follows: rabbit albumin and human albumin, about 6 days; rabbit γ globulin and human γ globulin, 12–14 days. Until the age of about 3 weeks, renal excretion of iodide was very inefficient. Consequently free I accumulated in the stomachs, and the whole body radio-activity greatly exceeded that due to retained labelled protein.

摘要

对出生后第1至6周的幼兔体内I标记的兔和人白蛋白及γ球蛋白的分解代谢进行了研究。根据经生长校正后的血浆浓度计算，半衰期在整个这一时期大致恒定，具体如下：兔白蛋白和人白蛋白约为6天；兔γ球蛋白和人γ球蛋白为12 - 14天。在大约3周龄之前，碘化物的肾排泄效率很低。因此，游离碘在胃中蓄积，全身放射性大大超过因保留的标记蛋白所致的放射性。