Bobrov V I, Beletskaia G T, Nazarova O I, Iakovlev V P
Antibiotiki. 1984 Mar;29(3):220-3.
The use of sulfalen and sulfadimethoxine in combination with acetylsalicylic acid resulted in the decreased binding of the sulfanilamides by serum proteins, most pronounced with respect to sulfadimethoxine. The decreased binding of the drugs by serum proteins in rabbits was accompanied by decreased elimination of sulfalen and increased excretion of sulfadimethoxine from the host. The different effect of acetylsalicylic acid on the kinetics of sulfalen and sulfadimethoxine in the rabbits was partially due to the unequivalent effect of the decreased binding of the sulfanilamides by the serum proteins on their combined use.
将磺胺二甲嘧啶和磺胺甲恶唑与乙酰水杨酸联合使用会导致血清蛋白对磺胺类药物的结合减少，其中对磺胺二甲嘧啶的影响最为明显。兔血清蛋白对药物结合的减少伴随着磺胺甲恶唑消除的减少和磺胺二甲嘧啶从宿主体内排泄的增加。乙酰水杨酸对兔体内磺胺甲恶唑和磺胺二甲嘧啶动力学的不同影响部分归因于血清蛋白对磺胺类药物结合减少对其联合使用的不等效作用。
