Furst D E, Levine S, Srinivasan R, Metzger A L, Bangert R, Paulus H E
Arthritis Rheum. 1977 Nov-Dec;20(8):1473-80. doi: 10.1002/art.1780200805.
In a double-blind study, patients were randomly selected for treatment using conventional doses (CD; 50 mg) or high doses (HD; 150 mg) of sodium aurothiomalate given weekly by injection. Twenty-three patients were assigned to the CD group and 24 to the HD group. Neither efficacy nor toxicity correlated with serum gold concentrations. Conventional doses were as efficacious as high doses with respect to both rapidity and degree of response. However, side effects were much more frequent and severe in the HD group. Thus there is no reason to recommend a 150 mg weekly dosage regimen.
在一项双盲研究中，患者被随机选择接受治疗，采用每周注射硫代苹果酸金钠的常规剂量（CD；50毫克）或高剂量（HD；150毫克）。23名患者被分配到CD组，24名患者被分配到HD组。疗效和毒性均与血清金浓度无关。在反应速度和程度方面，常规剂量与高剂量一样有效。然而，HD组的副作用更为频繁和严重。因此，没有理由推荐每周150毫克的给药方案。
