Griffin A J, Gibson T, Huston G, Taylor A
Ann Rheum Dis. 1981 Jun;40(3):250-3. doi: 10.1136/ard.40.3.250.
Maintenance treatment with chrysotherapy was given to 44 rheumatoid patients after a total of 1.0 g weekly injections of sodium aurothiomalate. 21 patients continued with 50 mg injections every 2 weeks, and 23 patients received the same dose at 4-week intervals. Their progress was followed over 1 year, after which time their clinical improvements were equally well sustained. Toxicity was greater in those patients receiving fortnightly injections. Five patients suffered a relapse after 8 months. These were not related to the frequency of injections nor to the serum gold levels. There appeared to be no advantage in maintenance injections at fortnightly intervals.
44名类风湿性关节炎患者在每周注射总计1.0克硫代苹果酸金钠后，接受金疗法维持治疗。21名患者每2周继续注射50毫克，23名患者每4周接受相同剂量注射。对他们进行了1年的随访，此后他们的临床改善情况同样得到良好维持。接受每两周一次注射的患者毒性更大。5名患者在8个月后复发。这些复发与注射频率和血清金水平均无关。每两周进行一次维持注射似乎没有优势。
