类风湿关节炎的维持性金疗法：两种剂量方案的比较
Maintenance chrysotherapy in rheumatoid arthritis: a comparison of 2 dose schedules.
作者信息
Griffin A J, Gibson T, Huston G, Taylor A
出版信息
Ann Rheum Dis. 1981 Jun;40(3):250-3. doi: 10.1136/ard.40.3.250.
Abstract
Maintenance treatment with chrysotherapy was given to 44 rheumatoid patients after a total of 1.0 g weekly injections of sodium aurothiomalate. 21 patients continued with 50 mg injections every 2 weeks, and 23 patients received the same dose at 4-week intervals. Their progress was followed over 1 year, after which time their clinical improvements were equally well sustained. Toxicity was greater in those patients receiving fortnightly injections. Five patients suffered a relapse after 8 months. These were not related to the frequency of injections nor to the serum gold levels. There appeared to be no advantage in maintenance injections at fortnightly intervals.
摘要
44名类风湿性关节炎患者在每周注射总计1.0克硫代苹果酸金钠后，接受金疗法维持治疗。21名患者每2周继续注射50毫克，23名患者每4周接受相同剂量注射。对他们进行了1年的随访，此后他们的临床改善情况同样得到良好维持。接受每两周一次注射的患者毒性更大。5名患者在8个月后复发。这些复发与注射频率和血清金水平均无关。每两周进行一次维持注射似乎没有优势。
相似文献
1
Maintenance chrysotherapy in rheumatoid arthritis: a comparison of 2 dose schedules.类风湿关节炎的维持性金疗法：两种剂量方案的比较
Ann Rheum Dis. 1981 Jun;40(3):250-3. doi: 10.1136/ard.40.3.250.
2
Comparison of two maintenance schedules of chrysotherapy in rheumatoid arthritis: preliminary report.类风湿关节炎中两种金疗法维持方案的比较：初步报告。
Rheumatol Rehabil. 1978;Suppl:99-104. doi: 10.1093/rheumatology/xvii.suppl.99.
3
Long-term chrysotherapy in rheumatoid arthritis.类风湿关节炎的长期金疗法
Arthritis Rheum. 1979 Feb;22(2):105-10. doi: 10.1002/art.1780220201.
4
Corneal chrysiasis and clinical improvement with chrysotherapy in rheumatoid arthritis.类风湿关节炎中的角膜金沉着症及金疗法的临床改善
Ann Rheum Dis. 1981 Dec;40(6):564-6. doi: 10.1136/ard.40.6.564.
5
Comparison of two dosage schedules of gold salts in the treatment of rheumatoid arthritis. Relationship of serum gold levels to therapeutic response.金盐两种给药方案治疗类风湿关节炎的比较。血清金水平与治疗反应的关系。
Arthritis Rheum. 1977 Jul-Aug;20(6):1179-87. doi: 10.1002/art.1780200604.
6
A comparison of conventional and low dose sodium aurothiomalate treatment in rheumatoid arthritis.类风湿关节炎中常规剂量与低剂量金硫葡糖治疗的比较。
Br J Rheumatol. 1983 May;22(2):82-8. doi: 10.1093/rheumatology/22.2.82.
7
Reinstitution of gold therapy in rheumatoid arthritis after mucocutaneous reactions.在出现皮肤黏膜反应后类风湿关节炎的金疗法再应用
J Rheumatol. 1975 Mar;2(1):21-7.
8
Postinjection nonvasomotor reactions during chrysotherapy. Constitutional and rheumatic symptoms following injections of gold salts.金疗法期间注射后的非血管舒缩反应。注射金盐后的体质性和风湿性症状。
Arthritis Rheum. 1977 Jul-Aug;20(6):1188-91. doi: 10.1002/art.1780200605.
9
Comparison between sodium aurothiomalate and auranofin in rheumatoid arthritis. Results of a two-year open randomized study.硫代苹果酸金钠与金诺芬治疗类风湿关节炎的比较。一项为期两年的开放性随机研究结果。
Scand J Rheumatol. 1987;16(3):177-84. doi: 10.3109/03009748709165271.
10
Gold levels in serum during the treatment of rheumatoid arthritis with gold sodium thiomalate.用硫代苹果酸金钠治疗类风湿关节炎期间血清中的金水平。
Aust N Z J Med. 1973 Oct;3(5):461-6. doi: 10.1111/j.1445-5994.1973.tb03123.x.
引用本文的文献
1
Oral gold for rheumatoid arthritis.用于类风湿性关节炎的口服金制剂
Br Med J (Clin Res Ed). 1984 Oct 6;289(6449):858-9. doi: 10.1136/bmj.289.6449.858.
本文引用的文献
1
Methods of scoring the progression of radiologic changes in rheumatoid arthritis. Correlation of radiologic, clinical and laboratory abnormalities.类风湿关节炎放射学改变进展的评分方法。放射学、临床及实验室异常的相关性。
Arthritis Rheum. 1971 Nov-Dec;14(6):706-20. doi: 10.1002/art.1780140605.
2
3
Monitoring serum gold values to improve chrysotherapy in rheumatoid arthritis.监测血清金值以改善类风湿关节炎的金疗法
Ann Rheum Dis. 1973 Mar;32(2):133-9. doi: 10.1136/ard.32.2.133.
4
Serum gold determinations in patients with rheumatoid arthritis receiving sodium aurothiomalate.接受硫代苹果酸金钠治疗的类风湿性关节炎患者的血清金含量测定。
Ann Rheum Dis. 1973 May;32(3):228-32. doi: 10.1136/ard.32.3.228.
5
Gold salts in the treatment of rheumatoid arthritis. A double-blind study.金盐治疗类风湿性关节炎。一项双盲研究。
Ann Intern Med. 1974 Jan;80(1):21-6. doi: 10.7326/0003-4819-80-1-21.
6
Blood and urine gold levels during chrysotherapy for rheumatoid arthritis.类风湿关节炎金疗法期间的血液和尿液金水平。
Rheumatol Rehabil. 1975 Feb;14(1):13-8. doi: 10.1093/rheumatology/14.1.13.
7
Effect of gold treatment on the progression of erosions in RA patients.金制剂治疗对类风湿关节炎患者糜烂进展的影响。
Scand J Rheumatol. 1977;6(2):123-7. doi: 10.3109/03009747709095434.
8
Followup study of chrysotherapy.金疗法的随访研究。
Arthritis Rheum. 1979 Apr;22(4):423. doi: 10.1002/art.1780220418.
9
Long term chrysotherapy: incidence of toxicity and efficacy during sequential time periods.长期金疗法：连续时间段内的毒性发生率和疗效
Arthritis Rheum. 1979 May;22(5):495-501. doi: 10.1002/art.1780220509.
10
A double-blind trial of high versus conventional dosages of gold salts for rheumatoid arthritis.一项针对类风湿性关节炎的金盐高剂量与常规剂量的双盲试验。
Arthritis Rheum. 1977 Nov-Dec;20(8):1473-80. doi: 10.1002/art.1780200805.
Zotero 插件