Tsukamoto I, Nakata R, Kojo S
Department of Food Science and Nutrition, Nara Women's University, Japan.
Biochem Int. 1992 Sep;27(6):1047-50.
Lipopolysaccharide administered intraperitoneally to rats just after partial (70%) hepatectomy at the dose from 0.04 to 4 mg/kg body weight inhibited the induction of thymidylate synthase and thymidine kinase which are rate-determining enzymes of DNA synthesis, resulting in the impairment of DNA synthesis in the regenerating liver. This effect may be due to the hepato-toxic nature of endotoxin.
