雷公藤提取物治疗MRL-lpr小鼠可抑制肾病和关节炎，并延长生存期
Suppression of renal disease and arthritis, and prolongation of survival in MRL-lpr mice treated with an extract of Tripterygium wilfordii Hook f.
作者信息
Gu W Z, Banerjee S, Rauch J, Brandwein S R
机构信息
Department of Medicine, Montreal General Hospital Research Institute, Quebec, Canada.
出版信息
Arthritis Rheum. 1992 Nov;35(11):1381-6. doi: 10.1002/art.1780351122.
OBJECTIVE
Treatment of MRL-lpr/lpr mice with Tripterygium wilfordii Hook f (TWHf) to evaluate its effects on mortality, renal disease, and arthritis.
METHODS
Mice were fed water (group A, control), TWHf (group B), or first water and then TWHf (group C) from age 7 weeks until age 21 weeks.
RESULTS
Arthritis and glomerulonephritis were decreased in groups B and C mice, and survival was increased in group B mice.
CONCLUSION
TWHf decreases the mortality rate, and severity of glomerulonephritis and arthritis in MRL-lpr/lpr mice.
目的
用雷公藤（TWHf）治疗MRL-lpr/lpr小鼠，以评估其对死亡率、肾脏疾病和关节炎的影响。
方法
从7周龄到21周龄，给小鼠分别喂水（A组，对照组）、雷公藤（B组）或先喂水后喂雷公藤（C组）。
结果
B组和C组小鼠的关节炎和肾小球肾炎减轻，B组小鼠的存活率提高。
结论
雷公藤降低了MRL-lpr/lpr小鼠的死亡率、肾小球肾炎和关节炎的严重程度。
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