Traditional Chinese Medicine Hospital of Changping District, Beijing, 102200, China.
Institute of Clinical Medicine, China-Japan Friendship Hospital, Beijing, 100029, China.
Front Med. 2019 Oct;13(5):556-563. doi: 10.1007/s11684-018-0649-5. Epub 2019 Jan 2.
Tripterygium wilfordii Hook F (TwHF) and its extracts have long been used for the treatment of rheumatoid arthritis, autoimmune diseases, and kidney disease due to their anti-inflammatory, immunoregulatory, and other pharmacological effects. However, the clinical immunoregulatory effects of TwHF and its extracts remain unclear, so we reviewed their effects for use in clinical practice. This review provides a comprehensive summary of the recent literature on the immunoregulatory effects of TwHF and its extracts in clinical studies. TwHF and its extracts affect the proliferation and activation of Tand B cells; ratio of Tcell subsets; inflammatory response of monocytes, macrophages, and immunoglobulins; and secretion of many cytokines. Together, these effects dictate immune function in a variety of diseases. TwHF and its extracts can be used alone or in combination with existing therapies against many immune disorders through immunomodulation.
雷公藤（Tripterygium wilfordii Hook F）及其提取物由于具有抗炎、免疫调节等药理作用，长期以来一直被用于治疗类风湿关节炎、自身免疫性疾病和肾脏疾病。然而，雷公藤及其提取物的临床免疫调节作用尚不清楚，因此我们对其在临床实践中的应用效果进行了综述。本综述对雷公藤及其提取物在临床研究中的免疫调节作用的最新文献进行了全面总结。雷公藤及其提取物影响 T 细胞和 B 细胞的增殖和活化；T 细胞亚群的比例；单核细胞、巨噬细胞和免疫球蛋白的炎症反应；以及多种细胞因子的分泌。这些作用共同决定了多种疾病中的免疫功能。雷公藤及其提取物可以通过免疫调节单独使用或与现有的治疗方法联合用于治疗许多免疫紊乱。
