眠尔通对单核细胞中流产布鲁氏菌增殖的影响。
Effect of meprobamate on the multiplication of Brucella abortus in monocytes.
作者信息
KESSEL R W, BOUGHTON J, BRAUN W
出版信息
Science. 1961 Dec 8;134(3493):1882-3. doi: 10.1126/science.134.3493.1882.
Peritoneal mononuclear phagocytes (monocytes) obtained from guinea pigs that had been treated with meprobamate do not support, in vitro, the intracellular growth of smooth Brucella abortus that is characteristic of monocytes from untreated animals. This modification of intracellular events appears to be due to an indirect action of the drug, since meprobamate does not produce any effects following direct exposure of monocytes or bacteria to the drug in vitro. Furthermore, the brucellacidal activity of serum from animals exposed to meprobamate is not increased. An interaction between monocytes and a component in the serum of animals exposed to meprobamate is required for the altered intracellular events.
从已用眠尔通处理过的豚鼠获得的腹膜单核吞噬细胞（单核细胞），在体外不能支持流产布鲁氏菌光滑型菌株在细胞内生长，而未处理动物的单核细胞具有这种特征性生长。细胞内事件的这种改变似乎是由于该药物的间接作用，因为在体外将单核细胞或细菌直接暴露于该药物后，眠尔通不会产生任何影响。此外，暴露于眠尔通的动物血清的杀布鲁氏菌活性并未增加。细胞内事件的改变需要单核细胞与暴露于眠尔通的动物血清中的一种成分之间发生相互作用。
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