含庆大霉素脂质体增强牛单核细胞对流产布鲁氏菌的吞噬内杀伤作用。
Enhanced intraphagocytic killing of Brucella abortus in bovine mononuclear cells by liposomes-containing gentamicin.
作者信息
Dees C, Fountain M W, Taylor J R, Schultz R D
出版信息
Vet Immunol Immunopathol. 1985 Jan;8(1-2):171-82. doi: 10.1016/0165-2427(85)90120-5.
In vitro intraphagocytic killing of Brucella abortus in bovine mononuclear leukocytes was enhanced by cationic, anionic, and neutral multilamellar liposomes-containing gentamicin. Free gentamicin not entrapped in liposomes. and liposomes without antibiotic did not enhance intraphagocytic killing of B. abortus in bovine phagocytes. In vivo killing of B. abortus in guinea pigs was also enhanced by liposomes-containing gentamicin when compared to free gentamicin. Liposomes-containing alpha tocopherol acetate failed to enhance in vivo killing of B. abortus.
含有庆大霉素的阳离子、阴离子和中性多层脂质体可增强牛单核白细胞对流产布鲁氏菌的体外吞噬细胞内杀伤作用。未包裹在脂质体中的游离庆大霉素以及不含抗生素的脂质体均不能增强牛吞噬细胞对流产布鲁氏菌的吞噬细胞内杀伤作用。与游离庆大霉素相比，含有庆大霉素的脂质体也增强了豚鼠体内对流产布鲁氏菌的杀伤作用。含有醋酸α-生育酚的脂质体未能增强豚鼠体内对流产布鲁氏菌的杀伤作用。
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