Nielsen S V, Henrichsen J
World Health Organization Collaborating Centre for Reference and Research on Pneumococci, Statens Seruminstitut, Copenhagen, Denmark.
Clin Infect Dis. 1992 Nov;15(5):794-8. doi: 10.1093/clind/15.5.794.
Knowledge about the type distribution of Streptococcus pneumoniae is fundamental to ensure an effective formulation of pneumococcal vaccine, especially with the possibility of producing a polysaccharide-protein-conjugated vaccine for the prevention of invasive disease in children. During the 6-year period 1982-1987, we received and typed 10,298 isolates from patients with invasive pneumococcal disease: 7,812 (76%) from blood and 2,486 (24%) from CSF. Of all isolates, 81% were recovered from individuals in Europe and 23% were from children. In order of frequency, S. pneumoniae types 6A + 6B, 14, 18C, 19F, 1, 7F, 23F, 19A, 4, and 5 were most commonly isolated from children, and types 3, 1, 14, 7F, 4, 6A + 6B, 8, 23F, 9V, and 19F, from adults. The pneumococcal types in the currently available 23-valent vaccine represented 87% of all isolates in this study, but the proportion of vaccine types varied somewhat with age and source. In all pneumococcal groups included in the vaccine, the vaccine types represented > 80% of the isolates, except in groups 6, 15, and 18.
了解肺炎链球菌的类型分布是确保有效制定肺炎球菌疫苗的基础，尤其是在有可能生产多糖 - 蛋白质结合疫苗以预防儿童侵袭性疾病的情况下。在1982年至1987年的6年期间，我们接收并对10298株来自侵袭性肺炎球菌疾病患者的分离株进行了分型：7812株（76%）来自血液，2486株（24%）来自脑脊液。在所有分离株中，81%是从欧洲个体中分离得到的，23%是从儿童中分离得到的。按频率排序，6A + 6B、14、18C、19F、1、7F、23F、19A、4和5型肺炎链球菌最常从儿童中分离得到，而3、1、14、7F、4、6A + 6B、8、23F、9V和19F型则最常从成人中分离得到。目前可用的23价疫苗中的肺炎球菌类型占本研究中所有分离株的87%，但疫苗类型的比例随年龄和来源略有不同。在疫苗包含的所有肺炎球菌组中，疫苗类型占分离株的比例> 80%，6、15和18组除外。
