Borisova N A, Chandrasekkhar K
Biull Eksp Biol Med. 1978 Nov;86(11):586-9.
A change in the amount of protein in the neurons of the anterior and mediobasal hypothalamus of sexually mature male rats castrated neonatally was observed in the study using the interferometric method. A considerable increase was recorded in the dry weight of the neurons in the medial preoptic region and the arcuate and ventromedial nuclei of the hypothalamus. The most pronounced changes were observed in the nuclei of these neurons. The results obtained point to the influence of androgens on the hypothalamic structures responsible for the regulation of both cyclic and tonic release of gonadotropic hormones in sexually mature animals during sex differentiation of the brain.
在这项研究中，使用干涉测量法观察到，新生期阉割的性成熟雄性大鼠下丘脑前部和内侧基部神经元中的蛋白质含量发生了变化。视前内侧区以及下丘脑弓状核和腹内侧核的神经元干重有显著增加。在这些神经元的细胞核中观察到了最明显的变化。所得结果表明，在脑的性别分化过程中，雄激素对负责调节性成熟动物促性腺激素周期性和持续性释放的下丘脑结构有影响。
