Riddick D H, DeGrazia C T, Maenza R M
Fertil Steril. 1977 Nov;28(11):1220-5. doi: 10.1016/s0015-0282(16)42920-1.
Polyglactic acid and polyglycolic acid suture materials were compared in rat uterine and abdominal wall tissues for inflammatory response and tissue fibrosis. By 90 days after surgery, the tissue inflammatory reaction and fibrosis were significantly less in response to polyglactic acid suture (Vicryl) in both uterus and skin as compared with the response to polyglycolic acid (Dexon). In addition, the over-all tissue response in skin was significantly greater than that in uterus for both suture materials. The potential importance of tissue fibrosis--particularly in oviductal surgery, over and above the formation of adhesions between one organ and another--is emphasized. It is concluded that (1) the magnitude of tissue response to suture material varies for different tissues, (2) the degree of tissue wall fibrosis does not necessarily correspond to external tissue adhesions, (3) adhesions are maximal at the surgical knots regardless of the suture material used, and (4) polyglactic acid suture material may be preferable to polyglycolic acid suture material for infertility surgery, in which a minimum of tissue reaction is imperative.
在大鼠子宫和腹壁组织中，对聚乳酸和聚乙醇酸缝合材料的炎症反应和组织纤维化进行了比较。术后90天时，与聚乙醇酸（Dexon）相比，聚乳酸缝线（Vicryl）在子宫和皮肤中引起的组织炎症反应和纤维化明显更少。此外，对于两种缝合材料，皮肤中的总体组织反应均明显大于子宫中的反应。强调了组织纤维化的潜在重要性——特别是在输卵管手术中，除了一个器官与另一个器官之间形成粘连之外。得出的结论是：（1）不同组织对缝合材料的组织反应程度不同；（2）组织壁纤维化程度不一定与外部组织粘连相对应；（3）无论使用何种缝合材料，手术结处的粘连都是最大的；（4）对于不育手术而言，聚乳酸缝合材料可能比聚乙醇酸缝合材料更可取，因为不育手术必须将组织反应降至最低。
