Lee S, Chan E, Demacedo A R, Bacchi C E, Wolf P
Microsurgery. 1984;5(1):15-8. doi: 10.1002/micr.1920050104.
In order to observe the effectiveness of polyglycolic acid microsutures (Dexon on rat uterine anastomoses, 40 Lewis rats were subjected to two-layer (including the mucosa) and one-layer (avoiding the mucosa) interrupted anastomoses of the freshly severed uteri using Dexon sutures. They were killed at days 7, 14, 21, 30, 60, 90, 180, 270, and 360. There was intensive inflammatory reaction during days 7-14 that gradually subsided, and the inflammatory reaction was limited to the suture sites by days 21-30. Sutures were still detectable at the end of 2 months, but they were no longer recognized at the end of 3 months. As the sutures were completely absorbed, giant cells and granulomatous reactions completely cleared. By days 180, 270, and 360, the rat uteri in both groups were indistinguishable from nonoperated ones. In this observation, it was noted that the use of absorbable microsutures with the mucosa inclusion in the rat uterine anastomoses was equally effective as those without the mucosa, and Dexon microsutures showed no residual effects on the uterine reanastomoses.
为观察聚乙醇酸微缝线（德克斯缝线）对大鼠子宫吻合术的效果，40只刘易斯大鼠用德克斯缝线对新鲜切断的子宫进行了两层（包括黏膜层）和一层（避开黏膜层）间断吻合。分别在术后第7、14、21、30、60、90、180、270和360天处死大鼠。术后7 - 14天有强烈炎症反应，之后逐渐消退，到21 - 30天时炎症反应局限于缝线部位。2个月时仍可检测到缝线，但3个月时已无法识别。随着缝线完全吸收，巨细胞和肉芽肿反应完全清除。到180、270和360天时，两组大鼠子宫与未手术的大鼠子宫无差异。在此观察中，注意到在大鼠子宫吻合术中使用包含黏膜层的可吸收微缝线与不包含黏膜层的同样有效，且德克斯微缝线对子宫再吻合无残留影响。
