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全身性施瓦茨曼反应发病机制中循环纤维蛋白的网状内皮系统清除作用

Reticuloendothelial clearance of circulating fibrin in the pathogenesis of the generalized Shwartzman reaction.

作者信息

LEE L

出版信息

J Exp Med. 1962 May 1;115(5):1065-82. doi: 10.1084/jem.115.5.1065.

DOI:10.1084/jem.115.5.1065
PMID:14463528
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2137542/
Abstract

Intravenous injections of endotoxin or infusions of thrombin in the rabbit initiate intravascular coagulation but do not usually result in massive deposition of fibrin. It has been proposed that the reticuloendothelial system may function efficiently in the removal of circulating fibrin; its blockade permits reproduction of all of the features of the generalized Shwartzman reaction by infusions of thrombin. In the rabbit the reticuloendothelial system may constitute the major protective mechanism against the vasculo-occlusive lesions of the generalized Shwartzman reaction, which appears to be the direct consequence of intravascular fibrin formation and deposition.

摘要

给兔子静脉注射内毒素或输注凝血酶可引发血管内凝血，但通常不会导致大量纤维蛋白沉积。有人提出，网状内皮系统可能在清除循环纤维蛋白方面发挥有效作用；阻断该系统后，输注凝血酶可重现全身性施瓦茨曼反应的所有特征。在兔子身上，网状内皮系统可能构成针对全身性施瓦茨曼反应血管阻塞性病变的主要保护机制，全身性施瓦茨曼反应似乎是血管内纤维蛋白形成和沉积的直接后果。

相似文献

1
Reticuloendothelial clearance of circulating fibrin in the pathogenesis of the generalized Shwartzman reaction.全身性施瓦茨曼反应发病机制中循环纤维蛋白的网状内皮系统清除作用
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2
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本文引用的文献

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Am J Pathol. 1955 May-Jun;31(3):489-99.
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Studies on the pathogenesis of fever. I. The presence of transferable pyrogen in the blood stream following the injection of typhoid vaccine.发热发病机制的研究。I. 注射伤寒疫苗后血流中可转移热原的存在。
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