LINDEMANN B, SOLOMON A K
J Gen Physiol. 1962 Mar;45(4):801-10. doi: 10.1085/jgp.45.4.801.
A method has been devised to measure the permeability characteristics of the intestinal mucosal cells in the rat. The method makes use of an electrical recording balance to register changes in weight when the mucosal face of a small strip of intestine is exposed to anisotonic solutions. The permeability coefficient of the luminal surface of intestinal mucosal cells to water is measured as 0.15 cm(4)/OSM, sec. and reasons are adduced to suggest that the true value might be higher than this. The equivalent pore radius of the luminal face of the tissue, measured in experiments in which lipid-insoluble non-electrolytes have been used according to the method of Goldstein and Solomon, appears to be 4.0 A.
已设计出一种方法来测量大鼠肠黏膜细胞的通透性特征。该方法利用电子记录天平来记录一小段肠黏膜面暴露于非等渗溶液时的重量变化。测得肠黏膜细胞腔面的水通透性系数为0.15 cm(4)/OSM，秒。并提出理由表明真实值可能高于此值。根据戈尔茨坦和所罗门的方法，在使用脂溶性非电解质的实验中测得的组织腔面的等效孔径似乎为4.0埃。
