克罗恩病和乳糜泻患儿的肠道通透性
Intestinal permeability in children with Crohn's disease and coeliac disease.
作者信息
Pearson A D, Eastham E J, Laker M F, Craft A W, Nelson R
出版信息
Br Med J (Clin Res Ed). 1982 Jul 3;285(6334):20-1. doi: 10.1136/bmj.285.6334.20.
Abstract
Mannitol and lactulose were used as probe molecules to measure intestinal permeability in children with active small-bowel Crohn's disease and with untreated coeliac disease. Mannitol and lactulose were administered by mouth in a moderately hypertonic solution (580 mmol (mosmol)/l), and results were expressed as the ratio of the molecules excreted in urine over five hours. Patients with Crohn's disease had a sixfold increase in permeability (due to increased lactulose permeability) and those with coeliac disease a fivefold increase (due to decreased mannitol permeability). From these results the test offers potential as a noninvasive investigation in children with small-bowel disease.
摘要
甘露醇和乳果糖被用作探针分子，以测量患有活动性小肠克罗恩病和未经治疗的乳糜泻的儿童的肠道通透性。甘露醇和乳果糖以等渗溶液（580 mmol（毫渗量摩尔）/升）经口给药，结果以五小时内尿液中排泄的分子比例表示。克罗恩病患者的通透性增加了六倍（由于乳果糖通透性增加），乳糜泻患者的通透性增加了五倍（由于甘露醇通透性降低）。从这些结果来看，该测试有潜力作为小肠疾病儿童的一种非侵入性检查手段。
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