牛嗜铬细胞中的C型利钠肽。其生物合成与分泌的调节。

C-type natriuretic peptide in bovine chromaffin cells. The regulation of its biosynthesis and secretion.

作者信息

Babinski K, Féthière J, Roy M, De Léan A, Ong H

机构信息

Department of Pharmacology, Faculty of Medicine, University of Montréal, Qué, Canada.

出版信息

FEBS Lett. 1992 Nov 30;313(3):300-2. doi: 10.1016/0014-5793(92)81214-7.

DOI:10.1016/0014-5793(92)81214-7

PMID:1446750

Abstract

We report here the regulation of the biosynthesis and the secretion of C-type natriuretic peptide (CNP) in cultured bovine chromaffin cells. The combined treatment with protein kinase A and -C activators induced a 6-fold increase of intracellular levels of CNP-(1-103). The biosynthesized CNP-(1-103) was co-released with its mature forms, typically CNP-(51-103), upon stimulation by nicotine or depolarizing agents. This confirms the neuropeptidic character of this third member of the natriuretic peptide family, which might act as a neuromodulator or neurotransmitter.

摘要

我们在此报告培养的牛嗜铬细胞中C型利钠肽（CNP）生物合成和分泌的调节情况。蛋白激酶A和-C激活剂联合处理使细胞内CNP-(1-103)水平增加了6倍。经尼古丁或去极化剂刺激后，生物合成的CNP-(1-103)与其成熟形式（通常为CNP-(51-103)）共同释放。这证实了利钠肽家族第三个成员的神经肽特性，其可能作为神经调节剂或神经递质发挥作用。