Salmon J F, Murray A D
Department of Ophthalmology, University of Cape Town, South Africa.
Eye (Lond). 1992;6 ( Pt 3):267-72. doi: 10.1038/eye.1992.50.
Twelve patients with iridoschisis in one or both eyes were studied to determine the clinical features of the condition and to examine the relationship of iridoschisis to primary angle-closure glaucoma. A spectrum of iris pathology, from subtle intrastromal atrophy to extensive splitting of the anterior layer of iris with fibrillar disintegration, was found in the affected and fellow eyes. Gonioscopy revealed partial or complete angle closure, particularly involving the superior angle, in all patients. Seven had glaucomatous disc damage and five had normal discs. The mean axial length and anterior chamber depth measurements in patients with iridoschisis were similar to those found in matched patients with primary angle-closure glaucoma but were significantly less than the measurements found in matched normals (p < 0.001). This study suggests that iridoschisis is an unusual manifestation of iris stromal atrophy and results from intermittent or acute elevation of intraocular pressure. Primary angle-closure glaucoma should be excluded in patients who present with iridoschisis.
对12例单眼或双眼患有虹膜劈裂症的患者进行了研究，以确定该病的临床特征，并探讨虹膜劈裂症与原发性闭角型青光眼之间的关系。在患眼和对侧眼中发现了一系列虹膜病变，从细微的基质内萎缩到虹膜前层广泛分裂伴纤维状崩解。前房角镜检查显示所有患者均有部分或完全性房角关闭，尤其是上方房角。7例有青光眼性视盘损害，5例视盘正常。虹膜劈裂症患者的平均眼轴长度和前房深度测量值与匹配的原发性闭角型青光眼患者相似，但显著小于匹配的正常人群测量值（p < 0.001）。本研究提示，虹膜劈裂症是虹膜基质萎缩的一种不寻常表现，由眼压间歇性或急性升高所致。出现虹膜劈裂症的患者应排除原发性闭角型青光眼。
