链霉素生物合成的研究。
Studies on the biosynthesis of streptomycin.
作者信息
MAJUMDAR S K, KUTZNER H J
出版信息
Appl Microbiol. 1962 Mar;10(2):157-68. doi: 10.1128/am.10.2.157-168.1962.
Abstract
Myo-inositol, especially in combination with arginine, enhances streptomycin production. Compounds which show structural relationship with myo-inositol are ineffective.Myo-inositol decreases the incorporation of C(14)-glucose into streptomycin, particularly into streptidine. This effect suggests that myo-inositol is a precursor of the streptidine ring. Methionine stimulates antibiotic production in a synthetic medium but proves to be unfavorable in a complex medium. The gamma- and delta-isomers of hexachlorocyclohexane inhibit streptomycin formation. The formation of streptomycin by washed mycelium was studied. Essentially the same results were here obtained as with growing cultures.
摘要
肌醇，尤其是与精氨酸结合时，可提高链霉素的产量。与肌醇具有结构关系的化合物则无此效果。肌醇可减少C(14)-葡萄糖掺入链霉素中，尤其是掺入链霉胍中。这一效应表明肌醇是链霉胍环的前体。蛋氨酸在合成培养基中可刺激抗生素的产生，但在复合培养基中则不利。六六六的γ-和δ-异构体抑制链霉素的形成。对洗涤过的菌丝体产生链霉素的情况进行了研究。基本上得到了与生长培养物相同的结果。
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本文引用的文献
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[The significance of phosphorus in the biosynthesis of streptomycin].[磷在链霉素生物合成中的意义]
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