灰色链霉菌在链霉素生物合成中肌醇的作用
Myo-inositol in the biosynthesis of streptomycin by Streptomyces griseus.
作者信息
MAJUMDAR S K, KUTZNER H J
出版信息
Science. 1962 Mar 2;135(3505):734. doi: 10.1126/science.135.3505.734.
PMID:14468644
Abstract
When myo-inositol is present in a growing culture of Streptomyces griseus the yield of streptomycin is increased, and the amount of carbon-14-from uniformly labeled glucose-incorporated into the streptidine and streptobiosamine moieties of streptomycin is lowered by 41 percent and 21.7 percent, respectively. These results present strong indirect evidence for the participation of myo-inositol or its metabolic products in streptidine biosynthesis.
摘要
当肌醇存在于灰色链霉菌的生长培养物中时，链霉素的产量会增加，并且从均匀标记的葡萄糖掺入链霉素的链霉胍和链霉糖胺部分的碳-14量分别降低了41%和21.7%。这些结果为肌醇或其代谢产物参与链霉胍生物合成提供了有力的间接证据。
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