四肽QDPR是乙肝病毒前S2结构域内最小的免疫显性表位。
Tetrapeptide QDPR is a minimal immunodominant epitope within the preS2 domain of hepatitis B virus.
作者信息
Sominskaya I, Bichko V, Pushko P, Dreimane A, Snikere D, Pumpens P
机构信息
Latvian Medical Academy, Riga.
出版信息
Immunol Lett. 1992 Jul;33(2):169-72. doi: 10.1016/0165-2478(92)90043-n.
A hepatitis B virus preS2 deletion library with the preS2 sequence fused to the coat protein of the RNA phage fr (fr CP) as a carrier has been constructed and used for the approximate localization of epitope recognized by a panel of murine monoclonal anti-preS2 antibodies. DNA copies of putative preS2 epitopes were synthesized and cloned within the fr CP gene. Tetrapeptide Gln-Asp-Pro-Arg (QDPR) corresponding to the preS (132-135) sequence was found to be the minimal sufficient recognition site for one of the monoclonal antibodies, S26. The closely related tetrapeptide EDPR did not mimic the epitope activity of QDPR.
构建了一个乙型肝炎病毒前S2缺失文库，其中前S2序列与RNA噬菌体fr的衣壳蛋白（fr CP）融合作为载体，并用于一组鼠源单克隆抗前S2抗体所识别表位的大致定位。假定的前S2表位的DNA拷贝被合成并克隆到fr CP基因内。发现对应于前S（132 - 135）序列的四肽Gln-Asp-Pro-Arg（QDPR）是单克隆抗体S26的最小充分识别位点。与之密切相关的四肽EDPR不能模拟QDPR的表位活性。
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