携带来自乙型肝炎病毒表面抗原免疫显性区域的杂交乙型肝炎病毒核衣壳。
Hybrid hepatitis B virus nucleocapsid bearing an immunodominant region from hepatitis B virus surface antigen.
作者信息
Borisova G, Arya B, Dislers A, Borschukova O, Tsibinogin V, Skrastina D, Eldarov M A, Pumpens P, Skryabin K G, Grens E
机构信息
Institute of Molecular Biology, Latvian Academy of Sciences, Riga.
出版信息
J Virol. 1993 Jun;67(6):3696-701. doi: 10.1128/JVI.67.6.3696-3701.1993.
Abstract
A hepatitis B core antigen (HBcAg) gene bearing the 39-amino-acid-long domain A of hepatitis B surface antigen (HBsAg) within the HBcAg immunodominant loop has been constructed and expressed in Escherichia coli. Chimeric capsids demonstrated HBs but not HBc antigenicity and elicited in mice B-cell and T-cell responses against native HBcAg and HBsAg.
摘要
已构建出一种乙型肝炎核心抗原（HBcAg）基因，该基因在HBcAg免疫显性环内带有39个氨基酸长的乙型肝炎表面抗原（HBsAg）结构域A，并在大肠杆菌中表达。嵌合衣壳显示出HBs抗原性而非HBc抗原性，并在小鼠体内引发了针对天然HBcAg和HBsAg的B细胞和T细胞反应。
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