Johnson U, Kamme C, Laurell A B, Nilsson N I
Acta Pathol Microbiol Scand C. 1977 Feb;85(1):10-6. doi: 10.1111/j.1699-0463.1977.tb03604.x.
Twenty children with acute pneumococcal otitis media were studied. In 6 children the infection ran a normal course and healed after the first episode and in 14 it relapsed. The serum levels of the immunoglobulins IgG, IgA and IgM were normal in all 20 children. Specific antibodies to pneumococcal polysaccharide were found in all cases, with no differences in the titers between the relapsed cases and those that healed. The complement components were quantitated with electroimmuno assay. G1q proved depressed in 60 per cent of the relapsed cases and in 16 per cent of the healed cases. C1r and C1s were disproportionally high compared with the C1q levels. Furthermore, crossed immunoelectrophoresis revealed abnormal complexes composed of C1r and C1s, and complexes composed of C1r, C1s and C1 IA. These complexes were more pronounced in sera from the children with relapsing otitis media.
对20名急性肺炎球菌性中耳炎患儿进行了研究。6名患儿感染呈正常病程，首次发作后痊愈，14名患儿复发。所有20名患儿的血清免疫球蛋白IgG、IgA和IgM水平均正常。所有病例均发现了针对肺炎球菌多糖的特异性抗体，复发病例和痊愈病例之间的滴度无差异。用免疫电泳法对补体成分进行定量。结果显示，60%的复发病例和16%的痊愈病例中C1q降低。与C1q水平相比，C1r和C1s不成比例地升高。此外，交叉免疫电泳显示存在由C1r和C1s组成的异常复合物，以及由C1r、C1s和C1 IA组成的复合物。这些复合物在复发性中耳炎患儿的血清中更为明显。
