Prellner K, Nilsson N I
Acta Otolaryngol. 1982 Sep-Oct;94(3-4):275-82. doi: 10.3109/00016488209128914.
Complement components C1q, C1s, C3, C4, factor B and properdin were measured, together with C1 subcomponent complexes and Cq binding substances in acute and convalescent samples from patients with relapsing and non-relapsing otitis media due to S. pneumoniae and H. influenzae. Analysis of C1 subcomponent complexes together with the finding of low C1q levels gave evidence of a disturbed C1 function in acute OME. Furthermore, complement activation by the classical and by the alternative pathways was demonstrated. Complement aberrations were more pronounced in relapsing otitis than in non-relapsing otitis. C1q binding substances that might possibly cause the complement aberrations found were present in most of the patients.
对因肺炎链球菌和流感嗜血杆菌导致的复发性和非复发性中耳炎患者的急性和恢复期样本，检测了补体成分C1q、C1s、C3、C4、B因子和备解素，以及C1亚成分复合物和Cq结合物质。C1亚成分复合物分析以及低C1q水平的发现表明急性中耳炎中C1功能紊乱。此外，还证实了经典途径和替代途径的补体激活。复发性中耳炎中的补体异常比非复发性中耳炎更明显。大多数患者体内存在可能导致所发现的补体异常的C1q结合物质。
