Gomita Y, Furuno K, Yoshida T, Oishi R, Saeki K, Araki Y
Department of Hospital Pharmacy, Okayama University Medical School, Japan.
Jpn J Pharmacol. 1992 Nov;60(3):281-5. doi: 10.1254/jjp.60.281.
The influence of acute exposures to standard (ST) and nicotine-reduced (NR) cigarette smokes on the plasma concentration of orally administered indomethacin (IM, 5 mg/kg) was investigated in rats. IM plasma concentrations in the ST- and NR-groups were lower than those in the non-smoking control group, while the lowered effect in the NR-group was slightly weaker than in the ST-group. These results suggest that the plasma concentrations of IM administered orally are lowered by the acute exposure of cigarette smoke, and this influence may be attributed largely to constituents other than nicotine in the cigarette smoke as well as slightly attributable to nicotine.
研究了急性暴露于标准（ST）香烟烟雾和低尼古丁（NR）香烟烟雾对大鼠口服吲哚美辛（IM，5mg/kg）后血浆浓度的影响。ST组和NR组的IM血浆浓度低于非吸烟对照组，而NR组的降低作用略弱于ST组。这些结果表明，急性暴露于香烟烟雾会降低口服IM的血浆浓度，这种影响可能主要归因于香烟烟雾中除尼古丁以外的成分，也有一部分归因于尼古丁。
