Shiba M, Yamaguchi Y
Department of Surgery, Chiba University, School of Medicine.
Nihon Rinsho. 1992 Oct;50(10):2395-400.
In order to clarify the significance of the nuclear DNA ploidy pattern in primary lung cancer, recent reports of flow cytometric analysis of nuclear DNA are discussed. It has been reported in many institutes, that nuclear DNA ploidy pattern was a significant and an independent postsurgical prognostic factor in lung cancer, statistically. Diploidy tumors showed a better post-surgical outcome than aneuploid tumors. This fact is more evident in stage I tumor than in advanced cases and was more in squamous cell carcinomas than in adenocarcinomas. Some papers reported that tumors with a high DNA index showed more invasive character than that with a low DNA index with flow cytometric and histopathological examination. As the percentage of aneuploid tumor was much higher in primary lung cancer than in other cancers, more detailed characterization is believed to be needed in aneuploid tumors by means of other oncological analysis, e.g. growth factors or expression of oncogene products.
为了阐明原发性肺癌中核DNA倍体模式的意义，本文讨论了近期有关核DNA流式细胞术分析的报告。许多研究机构报告称，从统计学角度来看，核DNA倍体模式是肺癌术后一个重要且独立的预后因素。二倍体肿瘤的术后预后优于非整倍体肿瘤。这一事实在I期肿瘤中比在晚期病例中更为明显，在鳞状细胞癌中比在腺癌中更为显著。一些论文报道，通过流式细胞术和组织病理学检查发现，DNA指数高的肿瘤比DNA指数低的肿瘤具有更强的侵袭性。由于原发性肺癌中非整倍体肿瘤的比例远高于其他癌症，因此认为需要通过其他肿瘤学分析方法，如生长因子或癌基因产物的表达，对非整倍体肿瘤进行更详细的特征描述。
