杀虫脒急性中毒致死过程中不存在单胺氧化酶抑制作用的参与。

Lack of involvement of monoamine oxidase inhibition in the lethality of acute poisoning by chlordimeform.

作者信息

Robinson C P, Smith P W

出版信息

J Toxicol Environ Health. 1977 Oct;3(3):565-8. doi: 10.1080/15287397709529588.

Abstract

Depletion of serotonin or norepinephrine in male rats by pretreatment with p-chlorophenylalanine or DL-alpha-methyl-p-tyrosine, respectively, failed to reduce the lethality of the monoamine oxidase-inhibiting acaricide, chlordimeform. Administration of phenylephrine, a directly acting alpha-adrenergic agonist, with chlordimeform did not increase the lethality of chlordimeform. Thus, monoamine oxidase inhibition by chlordimeform does not seem to contribute to its lethality.

摘要

分别用对氯苯丙氨酸或DL-α-甲基对酪氨酸预处理雄性大鼠，以耗尽其血清素或去甲肾上腺素，但未能降低单胺氧化酶抑制性杀螨剂氯苯脒的致死率。将直接作用的α-肾上腺素能激动剂去氧肾上腺素与氯苯脒一起给药，并不会增加氯苯脒的致死率。因此，氯苯脒对单胺氧化酶的抑制作用似乎与其致死性无关。