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单胺氧化酶抑制作用,这是杀虫脒不太可能的作用方式。

MAO inhibition, an unlikely mode of action for chlordimeform.

作者信息

Neumann R, Voss G

出版信息

Experientia. 1977 Jan 15;33(1):23-4. doi: 10.1007/BF01936730.

Abstract

Inhibition constants of several formamidines, their corresponding formanilides and other representatives of compounds derived from aniline, such as phenylureas, N-phenyl-carbamates and acylanilides, were determined for rat liver monoamine oxidase. The reversability of the inhibition and the lack of correlation between inhibition potencies and toxicities of the compounds tested add to the opinion that MAO inhibition is not a prominent factor in chlordimeform poisoning.

摘要

测定了几种脒、其相应的甲酰苯胺以及其他源自苯胺的化合物代表物(如苯基脲、N-苯基氨基甲酸酯和酰基苯胺)对大鼠肝脏单胺氧化酶的抑制常数。所测试化合物抑制作用的可逆性以及抑制效力与毒性之间缺乏相关性,进一步支持了单胺氧化酶抑制不是杀虫脒中毒主要因素的观点。

相似文献

10
Biochemical and physiological effects of chlordimeform.杀虫脒的生化和生理效应
Environ Health Perspect. 1976 Apr;14:71-82. doi: 10.1289/ehp.761471.

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