Haviryaji K S, Srinivas R, Suryanarayana T, Vemuri M C
School of Life Sciences, University of Hyderabad, India.
Mol Cell Biochem. 1992 Oct 7;115(2):143-7. doi: 10.1007/BF00230324.
Levels of RNA, mRNA and separation of ribosomal proteins from control and ethanol treated rat liver, showed no change in total RNA content, but poly(A+)mRNA was reduced significantly in ethanolic rats. Ribosomal proteins S2, S3a, S3b, S4, L3, L4, L4a, L10a and L15 were found substantially reduced in experimental rat livers. This study suggests decrease in poly(A+) mRNA coupled with loss of ribosomal proteins must be responsible for decreased protein synthesis in chronic alcoholism.
对照大鼠肝脏和乙醇处理大鼠肝脏中的RNA、mRNA水平以及核糖体蛋白的分离结果显示，总RNA含量未发生变化，但乙醇处理大鼠中多聚腺苷酸（聚（A+））mRNA显著减少。实验大鼠肝脏中的核糖体蛋白S2、S3a、S3b、S4、L3、L4、L4a、L10a和L15大幅减少。这项研究表明，聚（A+）mRNA减少以及核糖体蛋白缺失必然是慢性酒精中毒中蛋白质合成减少的原因。
