Ward L C
Drug Alcohol Depend. 1987 Jul;19(4):333-44. doi: 10.1016/0376-8716(87)90020-2.
A suitable animal model that mimics the effects of chronic alcohol intake in man has long been sought. The ethanol-containing liquid diet, although often finding favour in a variety of experimental studies, has recently been criticised for being nutritionally inadequate. Results of this study indicate liquid diets are capable of maintaining the growth of female, but not male, rats at rates comparable to those of similar animals fed on commercially available rodent pellets or on laboratory-prepared pelleted diets. In addition preliminary data are reported indicating the suitability of this model for inducing tolerance to alcohol.
长期以来一直在寻找一种合适的动物模型，该模型能够模拟人类长期摄入酒精的影响。含乙醇的液体饲料尽管在各种实验研究中常受青睐，但最近因其营养不充分而受到批评。这项研究的结果表明，液体饲料能够维持雌性大鼠的生长，但不能维持雄性大鼠的生长，其生长速度与食用市售啮齿动物颗粒饲料或实验室制备的颗粒饲料的类似动物相当。此外，还报告了初步数据，表明该模型适用于诱导对酒精的耐受性。
