Animal models of chronic alcohol ingestion: the liquid diet.

A suitable animal model that mimics the effects of chronic alcohol intake in man has long been sought. The ethanol-containing liquid diet, although often finding favour in a variety of experimental studies, has recently been criticised for being nutritionally inadequate. Results of this study indicate liquid diets are capable of maintaining the growth of female, but not male, rats at rates comparable to those of similar animals fed on commercially available rodent pellets or on laboratory-prepared pelleted diets. In addition preliminary data are reported indicating the suitability of this model for inducing tolerance to alcohol.