PARKER C W, SHAPIRO J, KERN M, EISEN H N
J Exp Med. 1962 Apr 1;115(4):821-38. doi: 10.1084/jem.115.4.821.
Multifunctional derivatives of penicillenic acid are effective elicitors of wheal-and-erythema skin responses in humans allergic to penicillin. Of the effective derivatives, penicilloyl-polylysines are particularly attractive as skin test reagents because they appear to be incapable of inducing antibody formation. The skin responses are specifically inhibitable in most instances by homologous unifunctional haptens. The penicillenic acid derivatives which appear to be determinants of human allergic reactions to penicillin are: penicilloyl, penicillenate, and groups of the penamaldate-penilloaldehyde type. Of these, the most significant appears to be the penicilloyl-lysyl determinant.
青霉烯酸的多功能衍生物是对青霉素过敏的人类出现风团和红斑皮肤反应的有效激发剂。在有效的衍生物中,青霉噻唑基多聚赖氨酸作为皮肤试验试剂特别有吸引力,因为它们似乎不能诱导抗体形成。在大多数情况下,皮肤反应可被同源单功能半抗原特异性抑制。似乎是人类对青霉素过敏反应决定因素的青霉烯酸衍生物有:青霉噻唑基、青霉烯酸盐,以及青霉烷酸 - 青霉醛类型的基团。其中,最重要的似乎是青霉噻唑基 - 赖氨酰决定簇。