Head E, Milgram N W
Life Sciences Division, University of Toronto, Scarborough, Ontario, Canada.
Pharmacol Biochem Behav. 1992 Nov;43(3):749-57. doi: 10.1016/0091-3057(92)90404-4.
An open-field activity test was developed for studying the effect of a single oral dose (range of 0.1-5 mg/kg) of L-deprenyl on spontaneous behavior in the dog. A computer program was used to quantify observations of locomotor activity, directed sniffing, urination, grooming, inactivity, jumping, rearing, and vocalization during a 10-min baseline and posttreatment session. Three dose-dependent behavioral changes were observed: an overall decrease in directed sniffing, an increase in total locomotor activity in females, and a decrease in frequency of urination in males. These effects were only seen at the dose levels of 2 mg/kg or higher. Computer-assisted tracings of behavioral patterns showed increased stereotypical behavior and decreased exploratory behavior at the high-dose levels. These behavioral effects are most likely due to either increased levels of phenylethylamine resulting from inhibition of monoamine oxidase B and/or the production of amphetamines as a result of the metabolism of L-deprenyl.
为研究单次口服剂量（0.1 - 5毫克/千克范围）的左旋司来吉兰对犬自发行为的影响，开展了一项旷场活动测试。使用计算机程序对10分钟基线期和治疗后时段的运动活动、定向嗅探、排尿、梳理毛发、静止不动、跳跃、站立和发声观察进行量化。观察到三种剂量依赖性行为变化：定向嗅探总体减少、雌性总运动活动增加以及雄性排尿频率降低。这些效应仅在2毫克/千克或更高剂量水平出现。行为模式的计算机辅助追踪显示，高剂量水平下刻板行为增加而探索行为减少。这些行为效应很可能是由于单胺氧化酶B受抑制导致苯乙胺水平升高和/或左旋司来吉兰代谢产生苯丙胺所致。
