Romero J N, Scadding G
Royal National Throat, Nose and Ear Hospital, London, United Kingdom.
Rhinology. 1992 Sep;30(3):169-75.
This study was aimed to assess the usefulness of eosinophilia measurements in nasal smears (ENS) in the diagnosis of nasal allergy. Nasal smears were taken from 84 patients with histories suggestive of allergic rhinitis. The smears were stained by the Giemsa method and examined by light microscopy. Positive results were demonstrated in 69.2% of the samples. All the 84 patients also had a skin prick test (SPT); the perceniitage of correct correlation between ENS and SPT was 71.4%. Forty-two patients underwent nasal challenge test (NCT) and the percentage of correct correlation between ENS and NCT was 69%. Nine patients had negative SPT, but positive ENS. All were nasally challenged with 4 proving positive. This leaves 5 individuals (5.9% of the 84 studied) in the non-allergic rhinitis with eosinophilia category. Based on these findings, it is suggested that the assessment of eosinophils in nasal smears should be given more relevance and be more commonly used in the diagnosis of nasal allergy.
本研究旨在评估鼻涂片嗜酸性粒细胞计数（ENS）在鼻变态反应诊断中的作用。对84例有过敏性鼻炎病史的患者进行鼻涂片检查。涂片采用吉姆萨染色法，通过光学显微镜检查。69.2%的样本结果呈阳性。所有84例患者均进行了皮肤点刺试验（SPT）；ENS与SPT的正确相关性百分比为71.4%。42例患者接受了鼻激发试验（NCT），ENS与NCT的正确相关性百分比为69%。9例患者SPT阴性，但ENS阳性。所有患者均接受4种物质的鼻激发试验，结果均为阳性。这使得84例研究对象中有5例（5.9%）属于非变应性鼻炎伴嗜酸性粒细胞增多症。基于这些发现，建议鼻涂片嗜酸性粒细胞评估在鼻变态反应诊断中应得到更多重视并更广泛应用。
