Ellis Anne K, Keith Paul K
Curr Allergy Asthma Rep. 2006 May;6(3):215-20. doi: 10.1007/s11882-006-0037-0.
Nonallergic rhinitis with eosinophilia syndrome (NARES) is a clinical syndrome comprising symptoms consistent with allergic rhinitis in which an absence of atopy has been demonstrated by allergen skin testing, and nasal cytology analysis demonstrates more than 20% eosinophils. Anosmia is a prominent feature not shared with allergic rhinitis. The pathophysiology of NARES is poorly understood, but a key component involves a self-perpetuating, chronic eosinophilic nasal inflammation with development of nasal micropolyposis and polyposis. Mast cells likely play an important role as well. NARES is a risk factor for the development of nasal polyposis and aspirin sensitivity, as well as obstructive sleep apnea. Treatment consists mainly of intranasal corticosteroids with or without the addition of second-generation antihistamines and/or leukotriene-receptor antagonists.
嗜酸性粒细胞增多综合征性非变应性鼻炎（NARES）是一种临床综合征，其症状与变应性鼻炎一致，通过变应原皮肤试验已证实不存在特应性，且鼻细胞学分析显示嗜酸性粒细胞超过20%。嗅觉减退是变应性鼻炎所没有的突出特征。NARES的病理生理学尚不清楚，但一个关键因素涉及一种持续存在的慢性嗜酸性粒细胞性鼻炎症，并伴有鼻微小息肉和息肉形成。肥大细胞可能也起重要作用。NARES是鼻息肉形成、阿司匹林敏感性以及阻塞性睡眠呼吸暂停发生的危险因素。治疗主要包括鼻用糖皮质激素，可加用或不加用第二代抗组胺药和/或白三烯受体拮抗剂。
