Ramírez F C, Graham D Y
Department of Medicine, Baylor College of Medicine, Houston, Texas.
Am J Gastroenterol. 1992 Dec;87(12):1789-91.
Four patients with intractable hiccup were treated in a double-blind, randomized, placebo, cross-over study with an analogue of gamma-aminobutyric acid, Baclofen. There was a consistent and statistically significant (p = 0.03) improvement in hiccup severity with Baclofen, both subjectively (p = 0.03) and by hiccup-free periods (p = 0.003). The actual frequency of hiccup was not significantly altered by the medication. We propose that the mechanical aspects of hiccup are reduced by Baclofen, leading to a perceptual blockage and a decrease in the reflex severity induced by the gamma-aminobutyric acid analogue. We conclude that this medication may be useful for the treatment of intractable hiccup.
对4例顽固性呃逆患者进行了一项双盲、随机、安慰剂对照的交叉研究，使用γ-氨基丁酸类似物巴氯芬进行治疗。使用巴氯芬治疗后，呃逆严重程度在主观上（p = 0.03）以及通过无呃逆期（p = 0.003）均有持续且具有统计学意义（p = 0.03）的改善。呃逆的实际频率并未因药物治疗而发生显著改变。我们认为，巴氯芬可减轻呃逆的机械性方面，导致感觉性阻断，并降低γ-氨基丁酸类似物诱导的反射严重程度。我们得出结论，这种药物可能对治疗顽固性呃逆有用。
