Lassen J B
Psychopharmacology (Berl). 1977 Oct 20;54(2):153-7. doi: 10.1007/BF00426772.
Rats were kept on a 12-h light-dark cycle. One hour after the light was switched on, physiological saline, (+)-amphetamine 1 mg/kg, and H 77/77 5 mg/kg were injected s.c.; the number of groomings was counted 1-2 h after the treatments. (+)-Amphetamine and H 77/77 produced increased grooming which was antagonized by the tyrosine hydroxylase inhibitor H 44/68 (250 mg/kg), the dopamine-beta-hydroxylase inhibitor FLA 63 (40), the neuroleptics haloperidol (0.1 and 0.5), and clozapine (1 and 5). The (+)-amphetamine-induced grooming was also antagonized by the NA-receptor blocker aceperone (10) but not by the sedative phenothiazines mepazine (10) and diphenhydramine (20) nor diazepam (1). These results indicate that NA-release is involved in the mediation of (+)-amphetamine- and H 77/77-induced grooming. The inhibition of haloperidol and clozapine is presumably due to NA-receptor blockade.
大鼠饲养在12小时光照-黑暗周期中。开灯1小时后，皮下注射生理盐水、1毫克/千克的（+）-苯丙胺和5毫克/千克的H 77/77；处理后1-2小时统计理毛次数。（+）-苯丙胺和H 77/77引起理毛增加，酪氨酸羟化酶抑制剂H 44/68（250毫克/千克）、多巴胺-β-羟化酶抑制剂FLA 63（40）、抗精神病药物氟哌啶醇（0.1和0.5）以及氯氮平（1和5）可拮抗这种增加。（+）-苯丙胺诱导的理毛也可被去甲肾上腺素受体阻断剂醋哌隆（10）拮抗，但不能被镇静性吩噻嗪类药物美哌嗪（10）、苯海拉明（20）或地西泮（1）拮抗。这些结果表明，去甲肾上腺素释放参与介导（+）-苯丙胺和H 77/77诱导的理毛。氟哌啶醇和氯氮平的抑制作用可能是由于去甲肾上腺素受体阻断。
