4,α-二甲基间酪氨酸（H 77-77）在大鼠中产生多动的去甲肾上腺素能和多巴胺能机制的证据。 - Suppr

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Evidence for a noradrenergic and dopaminergic mechanism in the hyperactivity produced by 4, alpha-dimethyl-m-tyramine (H 77-77) in rats.

作者信息

Lassen J B

出版信息

Psychopharmacologia. 1974;37(4):331-40. doi: 10.1007/BF00428919.

DOI:10.1007/BF00428919

PMID:4136728

Abstract

摘要

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Evidence for a noradrenergic and dopaminergic mechanism in the hyperactivity produced by 4, alpha-dimethyl-m-tyramine (H 77-77) in rats.4,α-二甲基间酪氨酸（H 77-77）在大鼠中产生多动的去甲肾上腺素能和多巴胺能机制的证据。

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Evidence for a dopaminergic dominance in the 4,alpha-dimethyl-m-tyramine-induced hypermotility in mice.关于4,α-二甲基间酪氨酸诱导小鼠运动亢进中多巴胺能占主导地位的证据。

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本文引用的文献

IS IT POSSIBLE TO PREDICT THE CLINICAL EFFECTS OF NEUROLEPTIC DRUGS (MAJOR TRANQUILLIZERS) FROM ANIMAL DATA?I. "NEUROLEPTIC ACTIVITY SPECTRA" FOR RATS.能否根据动物实验数据预测神经安定药物（主要镇静剂）的临床效果？I. 大鼠的“神经安定活性谱”

Arzneimittelforschung. 1965 Feb;15:104-17.

ADRENERGIC MECHANISMS AND AMPHETAMINE INDUCED ABNORMAL BEHAVIOUR.肾上腺素能机制与苯丙胺诱发的异常行为

Acta Pharmacol Toxicol (Copenh). 1963;20:145-57. doi: 10.1111/j.1600-0773.1963.tb01731.x.

Tryptophan hydroxylase inhibition: the mechanism by which p-chlorophenylalanine depletes rat brain serotonin.色氨酸羟化酶抑制作用：对氯苯丙氨酸耗尽大鼠脑内5-羟色胺的机制。

Mol Pharmacol. 1967 May;3(3):274-8.

On the role of norepinephrine biosynthesis in the central action of amphetamine.去甲肾上腺素生物合成在苯丙胺中枢作用中的作用

Life Sci. 1967 Jun 1;6(11):1155-62. doi: 10.1016/0024-3205(67)90197-x.

Antiamphetamine effects following inhibition of tyrosine hydroxylase.酪氨酸羟化酶抑制后的抗苯丙胺作用。

J Pharmacol Exp Ther. 1966 Mar;151(3):339-52.

Special antagonism of amphetamine-induced abnormal behaviour. Inhibition of stereotyped activity with increase of some normal activities.苯丙胺诱导的异常行为的特殊拮抗作用。抑制刻板行为并增加一些正常活动。

Psychopharmacologia. 1965 May 21;7(6):416-22. doi: 10.1007/BF00402364.

Effects of some antidepressant drugs on the depletion of intraneuronal brain catecholamine stores caused by 4,alpha-dimethyl-meta-tyramine.某些抗抑郁药物对由4,α-二甲基间酪氨酸引起的神经元内脑儿茶酚胺储备耗竭的影响。

Eur J Pharmacol. 1969 Mar;5(4):367-73. doi: 10.1016/0014-2999(69)90114-9.

Is it possible to predict the clinical effects of neuroleptic drugs (major tranquillizers) from animal data? IV. An improved experimental design for measuring the inhibitory effects of neuroleptic drugs on amphetamine-or apomorphine-induced "Cheroing" and "agitation" in rats.能否从动物实验数据预测抗精神病药物（强效镇静剂）的临床效果？IV. 一种改进的实验设计，用于测量抗精神病药物对大鼠中苯丙胺或阿扑吗啡诱导的“刻板行为”和“激动”的抑制作用。

Arzneimittelforschung. 1967 Jul;17(7):841-54.

Mode of action of apomorphine and dexamphetamine on gnawing compulsion in rats.阿扑吗啡和右旋苯丙胺对大鼠啃咬强迫行为的作用机制

Psychopharmacologia. 1967;10(4):316-23. doi: 10.1007/BF00403900.

Evidence that the CCENTRAL ACTION OF (+)-amphetamine is mediated via catecholamines.（+）-苯丙胺的中枢作用是通过儿茶酚胺介导的证据。

Psychopharmacologia. 1967;10(4):289-97. doi: 10.1007/BF00403897.

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