Taudy M, Syka J, Popelár J, Ulehlová L
ENT Department, 1st Medical Faculty, Charles University, Prague, Czechoslovakia.
Audiology. 1992;31(5):293-9.
Ototoxic effects of cisplatin (1.5 mg/kg), cisplatin with mannitol (1.5 mg/kg cisplatin with 15 mg/kg mannitol) and carboplatin (6 mg/kg) were compared in guinea pigs treated 5 days a week for 5 consecutive weeks. Auditory thresholds were measured in awake animals by means of the compound action potential recorded from electrodes implanted near the round window. The endocochlear potential (EP) was measured in the first turn through the round window, and hair cell counts were estimated by the surface specimen technique. The most pronounced ototoxicity (threshold shifts and hair cell loss) was observed with pure cisplatin. Cisplatin with mannitol appeared to be less toxic than pure cisplatin, and carboplatin the least toxic. Even carboplatin produced significant threshold shifts, particularly at high frequencies, but they were not accompanied by hair cell loss. Values of EP were not different from those in normal control animals.
在每周治疗5天、连续治疗5周的豚鼠中，比较了顺铂（1.5毫克/千克）、顺铂与甘露醇联用（1.5毫克/千克顺铂与15毫克/千克甘露醇）和卡铂（6毫克/千克）的耳毒性作用。通过植入圆窗附近电极记录的复合动作电位，在清醒动物中测量听觉阈值。通过圆窗在第一圈测量内淋巴电位（EP），并通过表面标本技术估计毛细胞数量。观察到纯顺铂具有最明显的耳毒性（阈值变化和毛细胞损失）。顺铂与甘露醇联用的毒性似乎低于纯顺铂，而卡铂毒性最小。即使是卡铂也会产生明显的阈值变化，尤其是在高频时，但并未伴有毛细胞损失。EP值与正常对照动物的值没有差异。
