Delb W, Feilen S, Koch A, Federspil P
Universitäts-HNO-Klinik Homburg/Saar.
Laryngorhinootologie. 1993 Jan;72(1):24-7. doi: 10.1055/s-2007-997847.
The application of the potent anticancer drug cisplatin is limited by major side effects such as its ototoxicity and its nephrotoxicity. Since carboplatin has been introduced into clinical use, a platinum derivative with less pronounced ototoxicity and nephrotoxicity is available. The aim of this study was to quantify the ototoxicity of carboplatin comparing it to cisplatin using the wellknown guinea-pig model. Using morphological and functional methods it could be shown that the ototoxic damage was by far higher in a group which had received a total dose of 12 kg cisplatin/kg than in a group which had received a dosage of 90 mg carboplat/kg. Our investigations show that the ototoxic potential of cisplatin in the guinea-pig is more than 9 times higher than that of carboplatin.
强效抗癌药物顺铂的应用受到诸如耳毒性和肾毒性等主要副作用的限制。自从卡铂被引入临床使用以来，一种耳毒性和肾毒性不那么明显的铂衍生物就可供使用了。本研究的目的是使用著名的豚鼠模型，将卡铂与顺铂进行比较，以量化卡铂的耳毒性。通过形态学和功能学方法可以表明，接受12mg顺铂/千克总剂量的组的耳毒性损伤远比接受90mg卡铂/千克剂量的组高得多。我们的研究表明，顺铂在豚鼠中的耳毒性潜力比卡铂高9倍以上。
