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4,4'-二甲氧基-5,6,5',6'-二亚甲基二氧基联苯-2,2'-二羧酸二甲酯（DDB）对致癌物诱导的大鼠肝细胞核DNA损伤的保护作用。

Protective effect of dimethyl-4,4'-dimethoxy-5,6,5', 6'-dimethylene dioxybiphenyl-2,2'-dicarboxylate (DDB) against carcinogen-induced rat liver nuclear DNA damage.

作者信息

Qing W, Liu G

机构信息

Department of Pharmacology, Chinese Academy of Medical Sciences, Beijing.

出版信息

Biomed Environ Sci. 1992 Sep;5(3):201-7.

PMID:1449655
Abstract

The protective effect of DDB against carcinogen-induced DNA damage was examined in the present investigation. Preincubation of rat liver nuclei with DDB (1 mmol.L-1) resulted in 60% inhibition of binding of 3H-benzo(a)pyrene to nuclear DNA. Unscheduled DNA synthesis (UDS) induced by aflatoxin B1 (10(-7) mol.L-1) in freshly isolated rat hepatocytes was also inhibited by DDB (10(-6)-10(-3) mol.L-1). Oral administration of DDB at 200 mg.kg-1 once daily for 3 d induced a significant increase of liver cytosol glutathione-S-transferase and microsomal UDPG-transferase activity in mice. These results indicate that DDB is able to directly or indirectly antagonize certain carcinogen-induced DNA damages.

摘要

本研究检测了联苯双酯（DDB）对致癌物诱导的DNA损伤的保护作用。用DDB（1 mmol.L-1）预孵育大鼠肝细胞核，可使3H-苯并(a)芘与核DNA的结合受到60%的抑制。DDB（10(-6)-10(-3) mol.L-1）也可抑制黄曲霉毒素B1（10(-7) mol.L-1）在新鲜分离的大鼠肝细胞中诱导的DNA修复合成（UDS）。小鼠每日口服200 mg.kg-1的DDB，连续3天，可使肝脏胞液谷胱甘肽-S-转移酶和微粒体UDPG-转移酶活性显著增加。这些结果表明，DDB能够直接或间接拮抗某些致癌物诱导的DNA损伤。

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