乙酰胆碱酯酶：用于治疗阿尔茨海默病的抗胆碱酯酶药物基于结构的药物设计的多方面靶点。
Acetylcholinesterase: a multifaceted target for structure-based drug design of anticholinesterase agents for the treatment of Alzheimer's disease.
作者信息
Greenblatt Harry M, Dvir Hay, Silman Israel, Sussman Joel L
机构信息
Department of Structural Biology, Weizmann Institute of Science, Rehovot, Israel.
出版信息
J Mol Neurosci. 2003;20(3):369-83. doi: 10.1385/JMN:20:3:369.
PMID:14501022
Abstract
The structure of Torpedo californica acetylcholinesterase is examined in complex with several inhibitors that are either in use or under development for treating Alzheimer's disease. The noncovalent inhibitors vary greatly in their structures and bind to different sites of the enzyme, offering many different starting points for future drug design.
摘要
研究了加州电鳐乙酰胆碱酯酶与几种用于治疗阿尔茨海默病或正在研发的抑制剂的复合物结构。这些非共价抑制剂的结构差异很大，并且与该酶的不同位点结合，为未来药物设计提供了许多不同的起点。
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