Lee Soo Jae, Sekimoto Toshihiro, Yamashita Eiki, Nagoshi Emi, Nakagawa Atsushi, Tanaka Hideaki, Yoneda Yoshihiro, Tsukihara Tomitake
Institute for Protein Research, Osaka University, Japan.
Acta Crystallogr D Biol Crystallogr. 2003 Oct;59(Pt 10):1866-8. doi: 10.1107/s0907444903018328. Epub 2003 Sep 19.
The nuclear-transport protein importin-beta mediates the nuclear import of the transcription factor SREBP-2 without requiring adaptor proteins such as importin-alpha. An importin-beta-SREBP-2 HLHZ domain complex was purified and crystallized. The crystals belong to space group P2(1)2(1)2(1) and show diffraction to at least 3.0 A resolution. The unit-cell parameters are a = 101.0, b = 113.2, c = 240.0 A. Structure determination using the MAD or SAD method is under way.
