Berry M, Hubbard P, Butt A M
Neural Damage and Repair, Centre for Neuroscience Research, Hodgkin Building, GKT School of Biomedical Sciences, Guy's Campus, London Bridge, London SE1 1UL, UK.
J Neurocytol. 2002 Jul-Aug;31(6-7):457-67. doi: 10.1023/a:1025735513560.
We present evidence that NG2+ glia are an integral part of an oligodendrocyte/synantocyte (OS) lineage stream the progenitors of which begin to produce both glial phenotypes at about birth. The NG2 CSPG is differentially distributed within the OS lineage, being expressed in progenitors and synantocytes but not in oligodendrocytes. All cells in the OS lineage, except the primordial stem cells, express O4. The oligodendrocyte line reacts with CD9, but synantocytes are CD9-. Nonetheless, synantocytes are morphologically complex and specialised glia which contact axolemma in myelinated fibres at nodes of Ranvier and synaptic terminals, and form >99% of all NG2+ glia in the adult CNS. Thus, the other NG2+ phenotype, the adult oligodendrocyte progenitor cell (AOPC), constitutes a small population of <1% of all NG2+ glia in the mature CNS. AOPC are a heterogeneous set of cells probably originating from multiple sources which, by definition, produce oligodendrocytes in the adult to replace loss after trauma, demyelination and normal 'wear and tear'. The definitive functions of synantocytes remain undefined.
我们提供的证据表明，NG2+神经胶质细胞是少突胶质细胞/突触相关细胞（OS）谱系流的一个组成部分，其祖细胞在出生时左右开始产生两种神经胶质细胞表型。NG2硫酸软骨素蛋白聚糖（CSPG）在OS谱系中呈差异分布，在祖细胞和突触相关细胞中表达，但在少突胶质细胞中不表达。OS谱系中的所有细胞，除了原始干细胞，都表达O4。少突胶质细胞系与CD9反应，但突触相关细胞是CD9阴性。尽管如此，突触相关细胞是形态复杂且特化的神经胶质细胞，它们在郎飞结处与有髓纤维的轴膜和突触终末接触，并且在成体中枢神经系统中构成了所有NG2+神经胶质细胞的99%以上。因此，另一种NG2+表型，即成体少突胶质细胞祖细胞（AOPC），在成熟中枢神经系统中占所有NG2+神经胶质细胞的比例不到1%。AOPC是一组异质性细胞，可能起源于多个来源，根据定义，它们在成体中产生少突胶质细胞以替代创伤、脱髓鞘和正常“磨损”后的损失。突触相关细胞的确切功能仍不明确。
