Takahashi Satoru, Kitamura Tadaichi
Department of Urology, Faculty of Medicine, Tokyo University, Tokyo, Japan.
Curr Opin Obstet Gynecol. 2003 Oct;15(5):429-33. doi: 10.1097/00001703-200310000-00012.
To review recent literature on the electrical and magnetic stimulation of the sacral nerve roots and pelvic floor for the treatment of overactive bladder.
Overactive bladder is a common condition affecting millions of women worldwide, with a significant effect on quality of life. Electrical stimulation and neuromodulation of the sacral nerve roots have provided a useful alternative for these patients with satisfactory outcomes. The use of the procedures has been limited, however, mainly due to local discomfort/pain or invasiveness of the surgical procedure. Magnetic stimulation can activate deep neural structures by induced electric currents noninvasively. Recent investigations demonstrated that magnetic stimulation of the sacral roots suppressed detrusor overactivity more effectively compared with electrical stimulation. Clinical trials including randomized placebo-controlled studies demonstrated the excellent short-term effect of magnetic stimulation in the treatment of overactive bladder.
Magnetic stimulation appears to induce inhibitory effects on detrusor overactivity in a similar manner to electrical stimulation, with significant clinical advantages. Although further studies are needed to establish long-term efficacy, magnetic stimulation of the sacral nerve roots may be a promising alternative treatment for overactive bladder.
回顾近期有关骶神经根和盆底的电刺激及磁刺激治疗膀胱过度活动症的文献。
膀胱过度活动症是一种常见疾病,影响着全球数百万女性,对生活质量有重大影响。骶神经根的电刺激和神经调节为这些患者提供了一种有效的替代方法,且效果令人满意。然而,这些治疗方法的应用受到限制,主要是由于局部不适/疼痛或手术的侵入性。磁刺激可通过感应电流无创地激活深部神经结构。最近的研究表明,与电刺激相比,骶神经根磁刺激能更有效地抑制逼尿肌过度活动。包括随机安慰剂对照研究在内的临床试验证明了磁刺激治疗膀胱过度活动症的出色短期效果。
磁刺激似乎与电刺激一样,对逼尿肌过度活动具有抑制作用,且具有显著的临床优势。尽管需要进一步研究来确定其长期疗效,但骶神经根磁刺激可能是治疗膀胱过度活动症的一种有前景 的替代疗法。