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与贲门失弛缓症相关的非霍奇金食管淋巴瘤复发性上消化道出血。

Relapsing upper bleeding in non-Hodgkin's oesophageal lymphoma associated with achalasia.

作者信息

del Pozo García Andrés J, García Buey Luisa, Llorca Ignacio, Iscar Teresa, Barxias Montserrat, Cantero Perona José, Pajares José M

机构信息

Service of Gastroenterology, Hospital de la Princesa, Universidad Autónoma de Madrid, Madrid, Spain.

出版信息

Eur J Gastroenterol Hepatol. 2003 Oct;15(10):1127-30. doi: 10.1097/00042737-200310000-00011.

Abstract

Achalasia is a disease of unknown origin in which there is a denervation of the myenteric plexus on the smooth muscle of the lower oesophageal sphincter, causing a cardial stenosis and a loss of efficacy of oesophageal peristalsis. The predominant symptoms are dysphagia for solids and liquids and regurgitation of the retained food. Occasionally, there may be oesophageal haemorrhage as a consequence of oesophagitis and stasis ulcers. An important but uncommon complication is the development of oesophageal cancer, which is typically squamous cell carcinoma. We report an exceptional case of a 77-year-old woman with a long-term achalasia and mega-oesophagus who presented four episodes of upper gastrointestinal bleeding in a 2 month period. The patient underwent surgical resection of the 10 cm of distal oesophagus, performing a partial fundoplication, and the pathological study revealed an oesophageal infiltration by a low-grade non-Hodgkin's lymphoma. After an insidious outcome, she died on the 47th day after admission.

摘要

贲门失弛缓症是一种病因不明的疾病,其特征是食管下括约肌平滑肌的肌间神经丛去神经支配,导致贲门狭窄和食管蠕动功能丧失。主要症状为固体和液体食物吞咽困难以及潴留食物反流。偶尔,食管炎和淤滞性溃疡可能导致食管出血。一个重要但不常见的并发症是食管癌的发生,通常为鳞状细胞癌。我们报告了一例特殊病例,一名77岁女性,患有长期贲门失弛缓症和巨食管,在2个月内出现了4次上消化道出血。患者接受了10厘米远端食管的手术切除,并进行了部分胃底折叠术,病理研究显示为低级别非霍奇金淋巴瘤浸润食管。经过隐匿性病程后,她在入院后第47天死亡。

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