Asano Koji, Miki Jun, Maeda Shigetaka, Naruoka Takehito, Takahashi Hiroyuki, Oishi Yukihiko
Department of Urology, Jikei University School of Medicine, Tokyo, Japan.
J Urol. 2003 Oct;170(4 Pt 1):1209-12. doi: 10.1097/01.ju.0000085342.15918.d7.
We report on 48 clinicopathologic cases of inverted papilloma and present the clinical significance attributed to these lesions in terms of the current literature.
From 1976 to 2002 we had experience with 48 cases of inverted papilloma in urinary tract. We present the clinical features of these cases and report the results of prognosis research.
Patient age ranged from 24 to 82 years (mean 56). Coexistence of transitional cell carcinoma occurred in a different location in the bladder in 3 cases and within a single neoplasm in the ureter in 2. Followup data were available in 42 of the 48 cases. Followup ranged from 8 months to 23 years 6 months (mean 8 years 1 month). Of the 42 cases 3 (7%) had a recurrence and range from initial resection at 5 months, 1 year 4 months and 2 years 6 months, respectively.
Our study suggests that there are 2 types of urinary inverted papilloma. The lesions in 1 type behave in a benign fashion and in another they have malignant potential. At this time we have no strategy with which to distinguish the 2 types of urinary inverted papilloma. Our results indicate that we must follow all cases for at least more than 2 years after initial treatment.
我们报告48例倒置性乳头状瘤的临床病理病例，并根据当前文献阐述这些病变的临床意义。
1976年至2002年期间，我们诊治了48例泌尿道倒置性乳头状瘤病例。我们介绍了这些病例的临床特征，并报告了预后研究结果。
患者年龄在24岁至82岁之间（平均56岁）。3例患者膀胱不同部位同时存在移行细胞癌，2例患者输尿管单个肿瘤内存在移行细胞癌。48例患者中有42例有随访数据。随访时间从8个月至23年6个月不等（平均8年1个月）。42例患者中，3例（7%）复发，分别在初次切除后5个月、1年4个月和2年6个月复发。
我们的研究表明，泌尿道倒置性乳头状瘤有两种类型。一种类型的病变表现为良性，另一种则具有恶性潜能。目前我们尚无区分这两种泌尿道倒置性乳头状瘤的方法。我们的结果表明，初次治疗后我们必须对所有病例至少随访2年以上。
